Obesity and Underweight Are Associated with an Increased Risk of Death after Lung Transplantation

摘要: Rationale: Obesity is considered a relative contraindication to lung transplantation, based on studies that have not accounted for key confounders. Little known about the risk of death underweight candidates after transplantation. Objectives: To examine associations pretransplant obesity and with transplantation. Methods: We examined 5,978 adults cystic fibrosis, chronic obstructive pulmonary disease, diffuse parenchymal disease who underwent transplantation in United States between 1995 2003. used Cox models generalized additive association body mass index adjustment donor recipient factors. Measurements Main Results: The median follow-up time was 4.2 years. Compared normal weight recipients, multivariable-adjusted rates were 15% higher recipients (95% confidence interval, 3 28%), overweight 6 26%), 22% obese 8 39%). These relationships persisted when stratified by diagnosis. population attributable fraction 12% at 1 year 8% 5 years. Conclusions: Both are independent factors contributing up deaths first transplantation. Primary care providers pulmonologists should promote healthy patients long before considered.