Treatment strategies for amyloid A amyloidosis.
作者： T Pettersson , YT Konttinen , CPJ Maury
DOI: 10.1517/14656566.9.12.2117
关键词:
摘要: Background: Amyloid A (AA) amyloidosis is a serious complication of wide range chronic inflammatory, infectious and neoplastic diseases. longstanding overproduction the liver-synthesised cytokine-induced acute phase serum amyloid (SAA) protein key event in pathogenetic cascade leading to deposition AA tissues organs. Objective: The aim study was critically review treatment strategies amyloidosis. Methods: systematic literature conducted based on PubMed (January 1980 – April 2008) selected conference abstracts. Results/conclusions: current strategy for firmly knowledge underlying mechanism aims at reducing precursor load by intensive anti-inflammatory/immunosuppressive therapy and, instances, anticytokine (TNF-α, IL-1β or IL-6 blockade) therapy, or, when applicable, eradication an existing focus (surgery, anti...
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