Study on a Three-Step Rapid Assembly of Zolpidem and Its Fluorinated Analogues Employing Microwave-Assisted Chemistry.

摘要: We developed an efficient microwave-assisted three-step synthesis of zolpidem and its fluorinated analogues 1-3. The procedure relays on the utilization easily accessible inexpensive starting materials. Our protocol shows superior performance in terms yield purity products, compared to conventional heating systems. Notably, total time needed for reaction accomplishment is significantly lower comparing oil bath Finally, we have performed a detailed study preparation tartrate salt I, assessed particle-sizes using polarizing microscope. goal was select appropriate method that generates acceptable particle-size, since solid-size directly influences solubility biological fluids further bioavailability. believe disclosed will help produce lab-scale quantity derivatives 1-3, as well with suitable fine-particle size experimentation.