Activation of SRF-Regulated Chromosomal Templates by Rho-Family GTPases Requires a Signal that Also Induces H4 Hyperacetylation
作者： Arthur S Alberts , Olivier Geneste , Richard Treisman
DOI: 10.1016/S0092-8674(00)80941-1
关键词:
摘要: Constitutively active forms of the small GTPases RhoA (RhoA.V14) and Cdc42 (Cdc42.V12) induce expression extrachromosomal SRF reporter genes in microinjection experiments, but only Cdc42.V12 can efficiently activate a chromosomal template. Both SAPK/JNK-dependent or -independent signals cooperate with RhoA.V14 to reporters, it is SAPK/JNK activation by that allows templates. Cooperating be bypassed deacetylase inhibitors. Three findings show histone H4 hyperacetylation one target for cooperating signals, although alone not sufficient: (1) Cdc42.V12, RhoA.V14, induces hyperacetylation; (2) use same pathways (3) growth factor stress stimuli substantial hyperacetylation, detectable gene chromatin. These data establish link between signal-regulated acetylation events transcription.
elsevier.com
sci-hub.se 参考文章(55)
S. Cereghini, M. Yaniv, Assembly of transfected DNA into chromatin: structural changes in the origin-promoter-enhancer region upon replication. The EMBO Journal. ,vol. 3, pp. 1243- 1253 ,(1984) , 10.1002/J.1460-2075.1984.TB01959.X
D.R. Edwards, L.C. Mahadevan, Protein synthesis inhibitors differentially superinduce c-fos and c-jun by three distinct mechanisms: lack of evidence for labile repressors. The EMBO Journal. ,vol. 11, pp. 2415- 2424 ,(1992) , 10.1002/J.1460-2075.1992.TB05306.X
ARTHUR S. ALBERTS, JEFFREY A. FROST, ANDREW M. THORBURN, Rapid transcriptional assay for the expression of two distinct reporter genes by microinjection. DNA and Cell Biology. ,vol. 12, pp. 935- 943 ,(1993) , 10.1089/DNA.1993.12.935
L. P. O'Neill, B. M. Turner, Histone H4 acetylation distinguishes coding regions of the human genome from heterochromatin in a differentiation-dependent but transcription-independent manner. The EMBO Journal. ,vol. 14, pp. 3946- 3957 ,(1995) , 10.1002/J.1460-2075.1995.TB00066.X
S.W. Jeong, A. Stein, DNA sequence affects nucleosome ordering on replicating plasmids in transfected COS-1 cells and in vitro. Journal of Biological Chemistry. ,vol. 269, pp. 2197- 2205 ,(1994) , 10.1016/S0021-9258(17)42154-5
C. Van Lint, S. Emiliani, M. Ott, E. Verdin, Transcriptional activation and chromatin remodeling of the HIV-1 promoter in response to histone acetylation. The EMBO Journal. ,vol. 15, pp. 1112- 1120 ,(1996) , 10.1002/J.1460-2075.1996.TB00449.X
W D Pennie, G L Hager, C L Smith, Nucleoprotein structure influences the response of the mouse mammary tumor virus promoter to activation of the cyclic AMP signalling pathway. Molecular and Cellular Biology. ,vol. 15, pp. 2125- 2134 ,(1995) , 10.1128/MCB.15.4.2125
M. A. Price, F. H. Cruzalegui, R. Treisman, The p38 and ERK MAP kinase pathways cooperate to activate Ternary Complex Factors and c-fos transcription in response to UV light. The EMBO Journal. ,vol. 15, pp. 6552- 6563 ,(1996) , 10.1002/J.1460-2075.1996.TB01046.X
T.R. Hebbes, A.L. Clayton, A.W. Thorne, C. Crane-Robinson, Core histone hyperacetylation co-maps with generalized DNase I sensitivity in the chicken beta-globin chromosomal domain. The EMBO Journal. ,vol. 13, pp. 1823- 1830 ,(1994) , 10.1002/J.1460-2075.1994.TB06451.X
Tim R. Hebbes, Christopher H. Turner, Alan W. Thorne, Colyn Crane-Robinson, A “minimal epitope” anti-protein antibody that recognises a single modified amino acid Molecular Immunology. ,vol. 26, pp. 865- 873 ,(1989) , 10.1016/0161-5890(89)90143-0