Percutaneous liver biopsy in adult haemophiliacs with hepatitis C virus: safety of outpatient procedure and impact of human immunodeficiency virus coinfection on the spectrum of liver disease.

摘要: Both HCV and HIV are common in haemophiliacs previously treated with non-viral-inactivated clotting factor concentrates. Because of increased bleeding risks, little data available on the safety percutaneous outpatient liver biopsy (LBx) impact coinfection this population. This study aims at reporting our experience LBx a cohort infected describe spectrum disease coinfection. A retrospective review consecutive patients haemophilia who underwent was performed. All were positive for RNA by commercial assay received concentrate prior to biopsy. total 29 male (mean age 36, 24 A, five B, 44% coinfected HIV) successful without complication. Histologic activity index 6.44 advanced fibrosis (bridging fibrosis/cirrhosis) 31%. When stratified (n = 13) vs. negative 16), had higher scores proportion (54% 12%; P 0.0167) no differences age, demographic or other laboratory parameters. Multivariate logistic regression found that positivity independently associated (OR 3.7; 95% CI: 1.17-11.8; 0.026). Outpatient can be safely performed haemophilia. Despite similar an independent predictor fibrosis. These support hypothesis accelerates progression those highlights importance histology