Apraxia Impairs Intentional Retrieval of Incidentally Acquired Motor Knowledge

摘要: Apraxia caused by left hemispheric stroke typically impairs skilled sequential movements. After stroke, apraxic patients need to reacquire motor skills learning. The current study assessed for the first time incidental sequence learning in patients. Forty-eight human subjects (henceforth called “patients”) with affecting middle cerebral artery territory (18 apraxia and 30 without apraxia) 17 age-matched healthy controls were tested on a visuomanual serial reaction task. Subjects performed four blocks consisting of repetitions complex six element containing ambiguous pairwise transitions before new unfamiliar was introduced block 5. Reaction (RT) disadvantages this fifth indicated sequence-specific intentional retrieval learned knowledge subsequently free recall Voxel-based lesion-symptom mapping (VLSM) investigate lesion correlates deficits retrieving knowledge. Despite generally prolonged RTs, showed as could be observed nonapraxic controls. However, reduced sequence. VLSM revealed that impaired resulted from dorsal premotor cortex lesions. Apraxic dissociation preserved (sequence) deficient incidentally data suggest novel approaches treating should focus learning, but automatic rather than strategies enforced.