Study of the protective effect of vitamin C on testicular tissue following experimental unilateral cryptorchidism in rats.

作者: O. Azari , H. Gholipour , R. Kheirandish , H. Babaei , L. Emadi

DOI: 10.1111/AND.12106

关键词:

摘要: Summary This study investigated the role of vitamin C as an antioxidant in protecting testis against damage experimental unilateral cryptorchidism. Forty-five male Wistar Albino rats were divided into three groups. The control group had intact rats, cryptorchid and treatment that it received at a dose 50 mg kg−1 body weight intraperitoneal, once day, during period. Histopathological samples obtained from five cases 15 animals each 15, 30 60 days after induction results showed histopathological parameters (left) testes significantly decreased compared with (P < 0.05), improved all these (P < 0.05). In addition, left on noticeable adverse effects scrotal (right) Treatment It can be concluded rats.

参考文章(46)
Patrick F. Thonneau, Peggy Candia, Roger Mieusset, Cryptorchidism: incidence, risk factors, and potential role of environment; an update. Journal of Andrology. ,vol. 24, pp. 155- 162 ,(2003) , 10.1002/J.1939-4640.2003.TB02654.X
Ian D. Podmore, Helen R. Griffiths, Karl E. Herbert, Nalini Mistry, Pratibha Mistry, Joseph Lunec, Vitamin C exhibits pro-oxidant properties Nature. ,vol. 392, pp. 559- 559 ,(1998) , 10.1038/33308
Sebastian J. Padayatty, Mark Levine, New insights into the physiology and pharmacology of vitamin C Canadian Medical Association Journal. ,vol. 164, pp. 353- 355 ,(2001)
Dale S. Huff, David M. Fenig, Douglas A. Canning, Michael C. Carr, Steven A. Zderic, Howard M. Snyder III, Abnormal Germ Cell Development in Cryptorchidism Hormone Research in Paediatrics. ,vol. 55, pp. 11- 17 ,(2001) , 10.1159/000049957
Françoise Bauché, Marie-Hélène Fouchard, Bernard Jégou, Antioxidant system in rat testicular cells FEBS Letters. ,vol. 349, pp. 392- 396 ,(1994) , 10.1016/0014-5793(94)00709-8
B. P. Setchell, The Parkes Lecture. Heat and the testis Reproduction. ,vol. 114, pp. 179- 194 ,(1998) , 10.1530/JRF.0.1140179
Sebastian J. Padayatty, Arie Katz, Yaohui Wang, Peter Eck, Oran Kwon, Je-Hyuk Lee, Shenglin Chen, Christopher Corpe, Anand Dutta, Sudhir K Dutta, Mark Levine, Vitamin C as an Antioxidant: Evaluation of Its Role in Disease Prevention Journal of The American College of Nutrition. ,vol. 22, pp. 18- 35 ,(2003) , 10.1080/07315724.2003.10719272
Lisa M. Watts, Suzanne Hasthorpe, Pamela J. Farmer, John M. Hutson, Apoptotic cell death and fertility in three unilateral cryptorchid rat models. Urological Research. ,vol. 28, pp. 332- 337 ,(2000) , 10.1007/S002400000121