Total synthesis of (±)-hirsutine: application of phosphine-catalyzed imine-allene [4 + 2] annulation.
作者： Reymundo A. Villa , Qihai Xu , Ohyun Kwon
DOI: 10.1021/OL302077N
关键词:
摘要: The total synthesis of the indole alkaloid hirsutine has been achieved, with a key step being application our phosphine-catalyzed [4 + 2] annulation an imine ethyl α-methylallenoate. From commercially available indole-2-carboxaldehyde, target was synthesized in 14 steps and 6.7% overall yield.
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