Pharmacokinetics of oxymorphone in cats
作者： K. T. SIAO , B. H. PYPENDOP , S. D. STANLEY , J. E. ILKIW
DOI: 10.1111/J.1365-2885.2011.01271.X
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摘要: Siao, K. T., Pypendop, B. H., Stanley, S. D., Ilkiw, J. E. Pharmacokinetics of oxymorphone in cats. vet. Pharmacol. Therap. 34, 594–598. This study reports the pharmacokinetics spayed female cats after intravenous administration. Six healthy adult domestic shorthair were used. Oxymorphone (0.1 mg/kg) was administered intravenously as a bolus. Blood samples collected immediately prior to administration and at various times up 480 min following Plasma concentrations determined by liquid chromatography–mass spectrometry, plasma concentration–time data fitted compartmental models. A three-compartment model, with input elimination from central compartment, best described disposition The apparent volume distribution compartment steady state [mean ± SEM (range)] clearance terminal half-life [harmonic mean ± jackknife pseudo-SD 1.1 ± 0.2 (0.4–1.7) L/kg, 2.5 ± 0.4 (2.4–4.4) 26 ± 7 (18–38) mL/min.kg, 96 ± 49 (62–277) min, respectively. is characterized moderate short half-life.
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