3-Desoxyanthocyanidins from Arrabidaea chica.
作者： Bettina Zorn , Alfonso J. Garcı́a-Piñeres , Victor Castro , Renato Murillo , Gerardo Mora
DOI: 10.1016/S0031-9422(01)00038-3
关键词:
摘要: The new 3-desoxyanthocyanidins 6,7,3'-trihydroxy-5,4'-dimethoxy-flavylium and 6,7,3',4'-tetrahydroxy-5-methoxy-flavylium the known 6,7-dihydroxy-5,4'-dimethoxy-flavylium (Carajurin) were isolated by bioguided fractionation from leaves of Arrabidaea chica, with transcription factor NF-kappaB as target. structure Carajurone was revised to be 6,7,4'-trihydroxy-5-methoxy-flavylium. Additionally, flavone acacetin found. All structures mainly established on basis MS- NMR data (1H, 1H-1H COSY partly 13C, GHMQCR GHSQCR). Carajurin, which failed give a positive result in DPPH TLC assay completely inhibited NF-kappaB, but not NF-AT at 500 microM concentration.
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