The protective effect of losartan in the nephropathy of the diabetic rat includes the control of monoamine oxidase type A activity.

摘要: Abstract Monoamine oxidase activity (MAO-A and B) levels, as intracellular source of reactive oxygen species, might increase in diabetic nephropathy (DN) contributing to reduce dopamine levels unbalance kidney redox state. We explored the hypothesis that beneficial effects losartan, an angiotensin-II type 1 receptor (AT1) blocker, DN included control MAO levels. In kidneys normoglycemic diabetic, streptozotocin-injected (55 mg/kg) rats, treated or untreated with AT1 antagonist (20 mg/kg/day drinking water), we investigated radiochemically antioxidant enzymes including catalase, aldehyde dehydrogenase superoxide dysmuthase spectrophotometrically. addition, also evaluated malondialdehyde carbonylated protein spectrophotometrically indexes oxidative attack lipids proteins. Diabetic rats showed signs nephropathy, renal hypertrophy, proteinuria, high acethylglucosaminidase γ-glutamyltranspeptidase urinary kidneys, MAO-A catalase activities well were found significantly higher than ones. Interestingly, correlated not only but Our results indicate is be amongst mechanisms protection afforded by losartan DN. fact, prevention raise availability and, suggested correlation γ-GGT, tubular cells.