In Vitro AuNPs' Cytotoxicity and Their Effect on Wound Healing.
作者： Veronika Pivodová , Jana Franková , Adéla Galandáková , Jitka Ulrichová
DOI: 10.5772/61132
关键词:
摘要: Recently, due to their unique properties, gold nanoparticles (AuNPs) have been used in many biological applications. However, little is known about toxicity when they come into contact with a system. Based on the proposal that AuNPs can positive effect wound healing, present study investigated influence of negatively-charged-surface (average diameter 25-50 nm) viability normal human dermal fibroblasts (NHDF) and epidermal keratinocytes (NHEK). Moreover, we evaluated secretion proteins involved such as interleukin-8 - 12 (IL-8, IL-12), tumour necrosis factor-alpha (TNF-α), vascular endothelial growth factor (VEGF), basic fibroblast grow (bFGF), granulocyte-macrophage colony-stimulating (GM-CSF). The results showed were not toxic NHDF NHEK. They decrease AuNPs' production pro-inflammatory cytokines IL-6, IL-12 TNF-α, well angiogenesis VEGF bFGF. Thus, suggest could anti-inflammatory anti-angiogenic activity.
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