Genetics of cardiovascular disease with emphasis on atrial fibrillation.

作者: Ramon Brugada , Joseph Brugada , Robert Roberts

DOI: 10.1023/A:1009859119791

关键词:

摘要: Cardiology has embraced the techniques of molecular genetics later than other medical disciplines but is now completely submerged in genetic mapping cardiac diseases. The biology, and particular, their application to inherited diseases, have brought clinician scientist together an unparalleled dependence. chromosomal genes responsible for disease requires identification families with This step involves cooperation clinician. In order continue improving our understanding basis, it imperative raise awareness role Arrhythmias can also a familial origin not generally appreciated that atrial fibrillation could be inherited. last two years, we identified more 100 all over world individuals affected by form disease. With area on chromosome 10 carries gene causing some there ongoing research identify specific mutation. clinician/scientist relationship just started discoveries will probably direct how approach medicine future, from prevention diseases patients carrying susceptibility therapy those

参考文章(9)
AJ Marian, QT Yu, Raymond Workman, Gottfried Greve, Robert Roberts, Angiotensin-converting enzyme polymorphism in hypertrophic cardiomyopathy and sudden cardiac death The Lancet. ,vol. 342, pp. 1085- 1086 ,(1993) , 10.1016/0140-6736(93)92064-Z
Louis Wolff, Familial Auricular Fibrillation New England Journal of Medicine. ,vol. 229, pp. 396- 398 ,(1943) , 10.1056/NEJM194309022291002
Gregory W. Albers, Atrial Fibrillation and Stroke Archives of Internal Medicine. ,vol. 154, pp. 1443- 1448 ,(1994) , 10.1001/ARCHINTE.1994.00420130030006
José Girona, Anna Domingo, Dimpna Albert, Jaime Casaldàliga, Lluís Mont, Josep Brugada, Ramón Brugada, Fibrilación auricular familiar Revista Española de Cardiología. ,vol. 50, pp. 548- 551 ,(1997) , 10.1016/S0300-8932(97)73262-7
Qing Wang, Qiuyun Chen, Hua Li, Jeffrey A. Towbin, Molecular genetics of long QT syndrome from genes to patients. Current Opinion in Cardiology. ,vol. 12, pp. 310- 320 ,(1997) , 10.1097/00001573-199705000-00013
A.J. Marian, R. Roberts, Recent Advances in the Molecular Genetics of Hypertrophic Cardiomyopathy Circulation. ,vol. 92, pp. 1336- 1347 ,(1995) , 10.1161/01.CIR.92.5.1336
R. Brugada, L.L. Bachinski, R. Hill, R. Roberts, Familial atrial fibrillation is a genetically heterogeneous disease Journal of the American College of Cardiology. ,vol. 31, pp. 349- ,(1998) , 10.1016/S0735-1097(98)82159-1
William M. Feinberg, Prevalence, Age Distribution, and Gender of Patients With Atrial Fibrillation Archives of Internal Medicine. ,vol. 155, pp. 469- 473 ,(1995) , 10.1001/ARCHINTE.1995.00430050045005
Ramon Brugada, Terry Tapscott, Grazyna Z. Czernuszewicz, A.J. Marian, Anna Iglesias, Lluis Mont, Josep Brugada, Josep Girona, Anna Domingo, Linda L. Bachinski, Robert Roberts, Identification of a Genetic Locus for Familial Atrial Fibrillation The New England Journal of Medicine. ,vol. 336, pp. 905- 911 ,(1997) , 10.1056/NEJM199703273361302