Ion Movements in Gramicidin Channels

作者: S.B. Hladky , D.A. Haydon

DOI: 10.1016/S0070-2161(08)60444-X

关键词:

摘要: Publisher Summary This chapter discusses gramicidin with respect to its structure and why it is believed be a channel. The gramicidins, of which there are several, linear 15-amino acid polypeptides produced by Bacillus hreuis. naturally occurring mixture A, B, C in the approximate ratio 72 : 9 1. primary A unusual several respects. One properties that has greatly facilitated study readily measurable single-channel conductance duration. Unlike conductance, both frequency opening channels mean channel open time or duration strong functions membrane lipid. also gramicidins regard stability kinetics formation decomposition lipid membranes relation ion water permeability.

参考文章(70)
Valerie B. Myers, D.A. Haydon, Ion transfer across lipid membranes in the presence of gramicidin A Biochimica et Biophysica Acta (BBA) - Biomembranes. ,vol. 274, pp. 313- 322 ,(1972) , 10.1016/0005-2736(72)90179-4
S.B. Hladky, D.A. Haydon, Ion transfer across lipid membranes in the presence of gramicidin A Biochimica et Biophysica Acta (BBA) - Biomembranes. ,vol. 274, pp. 294- 312 ,(1972) , 10.1016/0005-2736(72)90178-2
P. Läuger, Ion transport through pores: A rate-theory analysis Biochimica et Biophysica Acta (BBA) - Biomembranes. ,vol. 311, pp. 423- 441 ,(1973) , 10.1016/0005-2736(73)90323-4
R. Henze, E. Neher, T. L. Trapane, D. W. Urry, Dielectric relaxation studies of ionic processes in lysolecithin-packaged gramicidin channels The Journal of Membrane Biology. ,vol. 64, pp. 233- 239 ,(1982) , 10.1007/BF01870890
D. W. Urry, J. T. Walker, T. L. Trapane, Ion interactions in (1-13C)D-Val8 and D-Leu14 analogs of gramicidin A, the helix sense of the channel and location of ion binding sites. The Journal of Membrane Biology. ,vol. 69, pp. 225- 231 ,(1982) , 10.1007/BF01870401
Erwin Neher, Hansjörg Eibl, The influence of phospholipid polar groups on gramicidin channels Biochimica et Biophysica Acta (BBA) - Biomembranes. ,vol. 464, pp. 37- 44 ,(1977) , 10.1016/0005-2736(77)90368-6
D. W. Urry, The Gramicidin A Transmembrane Channel: A Proposed π(L,D) Helix Proceedings of the National Academy of Sciences of the United States of America. ,vol. 68, pp. 672- 676 ,(1971) , 10.1073/PNAS.68.3.672
V.S. Rudnev, L.N. Ermishkin, L.A. Fonina, Yu.G. Rovin, The dependence of the conductance and lifetime of gramicidin channels on the thickness and tension of lipid bilayers Biochimica et Biophysica Acta. ,vol. 642, pp. 196- 202 ,(1981) , 10.1016/0005-2736(81)90149-8