Efficacy of combining timolol with other antiglaucoma medications

摘要: The ocular hypotensive effects of timolol and a carbonic anhydrase inhibitor (acetazolamide or methazolamide) are partially additive; that is, concurrent administration these drugs produces clinically useful reduction in intraocular pressure which is greater than the effect either medication alone, but less arithmetic sum individual drugs. Similarly, miotic agent (pilocarpine, carbachol, echothiophate iodide) response most glaucoma patients. In contrast, epinephrine poorly additive. Only minority patients maintain substantial, longterm when added to regimen vice versa. Ophthalmologists prescribing for receiving other drug urged use therapeutic trial one eye several weeks determine efficacy treatment. addition medical uncontrolled on maximum tolerated antiglaucoma therapy (a agent, inhibitor) reduces substantially one-third one-half cases.