Amiodarone in Patients with Congestive Heart Failure and Asymptomatic Ventricular Arrhythmia

摘要: Background Asymptomatic ventricular arrhythmias in patients with congestive heart failure are associated increased rates of overall mortality and sudden death. Amiodarone is now used widely to prevent tachycardia fibrillation. We conducted a trial determine whether amiodarone can reduce asymptomatic arrhythmias. Methods double-blind, placebo-controlled protocol which 674 symptoms failure, cardiac enlargement, 10 or more premature contractions per hour, left ejection fraction 40 percent less were randomly assigned receive (336 patients) placebo (338 patients). The primary end point was mortality, the median follow-up 45 months (range, 0 54). Results There no significant difference between two treatment groups (P = 0.6). two-year actuarial survival rate 69...