Nanotech-derived topical microbicides for HIV prevention: the road to clinical development.

摘要: More than three decades since its discovery, HIV infection remains one of the most aggressive epidemics worldwide, with more 35 million people infected. In sub-Saharan Africa, heterosexual transmissions represent nearly 80% new infections, 50% these occurring in women. an effort to stop dramatic spread epidemic, preventive treatments, such as microbicides, have been developed. Nanotechnology has revolutionized this field by designing and engineering novel highly effective nano-sized materials microbicide candidates. This review illustrates recent advances nanotech-derived prevention strategies, well main steps required translate promising vitro results into clinical trials.