Intravenous Administration of Pulsatile Gonadotropin Releasing Hormone in Hypothalamic Amenorrhea: Effects of Dosage*

摘要: Eighteen women with well characterized hypothalamic amenorrhea underwent 30cycles of pulsatile GnRH treatment in an effort to examine the role dosage pituitary and ovarian responses. was administered iv at 2 doses (25 100 ng/kg bolus) a physiological range frequencies (90 60 min) follicular phase induced cycles. After demonstration ovulation by ultrasound clinical parameters, frequency administrationwas progressively slowed from every min 90 then 240 mimic theslowing endogenous LH secretion that occurs during luteal normal women. The results these cycles were compared those 62 ovulatory Overall biochemical revealed following. Patients receiving 25ng/kg successfully ovulated only 80% time, recruitment single dominant follicle. Two 5 patients became pregnant. Peak estradiol levels signific...