Consensus statement on the pathology of IgG4-related disease

摘要: IgG4-related disease is a newly recognized fibro-inflammatory condition characterized by several features: tendency to form tumefactive lesions in multiple sites; characteristic histopathological appearance; and-often but not always-elevated serum IgG4 concentrations. An international symposium on was held Boston, MA, 4-7 October 2011. The organizing committee comprising 35 experts from Japan, Korea, Hong Kong, the United Kingdom, Germany, Italy, Holland, Canada, and States, including clinicians, pathologists, radiologists, basic scientists. This group represents broad subspecialty expertise pathology, rheumatology, gastroenterology, allergy, immunology, nephrology, pulmonary medicine, oncology, ophthalmology, surgery. histopathology of specific focus symposium. primary purpose this statement provide practicing pathologists with set guidelines for diagnosis disease. rests combined presence appearance increased numbers IgG4⁺ plasma cells. critical features are dense lymphoplasmacytic infiltrate, storiform pattern fibrosis, obliterative phlebitis. We propose terminology scheme that based primarily morphological biopsy. Tissue counts IgG4:IgG ratios secondary importance. proposed do supplant careful clinicopathological correlation sound clinical judgment. As spectrum continues expand, we advocate use strict criteria accepting entities or sites as components spectrum.