Metaxin 3 is a Highly Conserved Vertebrate Protein Homologous to Mitochondrial Import Proteins and GSTs

摘要: ABSTRACT Metaxin 3 genes are shown to be widely conserved in vertebrates, including mammals, birds, fish, amphibians, and reptiles. genes, however, not found invertebrates, plants, bacteria. The predicted metaxin proteins were identified by their homology the encoded zebrafish Xenopus cDNAs. Further evidence that they was provided presence of GST_N_Metaxin, GST_C_Metaxin, Tom37 protein domains, absence other major domains. Alignment human 1 amino acid sequences showed 45% identities, while 2 had 23% identities. These results indicate is a distinct metaxin. A wide variety vertebrate species—including human, zebrafish, Xenopus, dog, shark, elephant, panda, platypus—had same adjacent gene. In particular, thrombospondin 4 gene (THBS4) next (MTX3). By comparison, (THBS3) (MTX1). Phylogenetic analysis 3, 1, formed separate clusters, but with all three metaxins being derived from common ancestor. Alpha-helices dominate secondary structures proteins. Little beta-strand present. pattern 9 helical segments also for 2.