[Epidermal aging and anti-aging strategies].

摘要: Epithelial senescence is a complex process depending on intrinsic as well extrinsic factors (e.g., UV or IR light, tobacco smoke) and must be seen in the context of aging especially corium subcutis. Morphological alterations become apparent form epithelial atrophy, structural changes within basal membrane, decrease cell count melanocytes Langerhans cells. Signs cellular are reduced proliferation keratinocytes, cumulation dysplastic various mutations c-Fos/c-Jun, STAT3, FoxO1), multiple lipid amino acid metabolic aberrations production advanced glycation endproducts). This causes functional physical (lipid deficiency, water distribution dysfunction, lack hygroscopic substances), chemical (pH conditions, oxygen radicals), immunological barrier. Prophylactically, barrier-protective care products, antioxidant substances vitamin C, B3, E, polyphenols, flavonoids), sunscreen products/measurements, retinoids used. For correcting aged epidermis, peelings (fruit acids, β-hydroxy acid, trichloroacetic phenolic compounds), non-ablative (IPL, PDL, Nd:YAG) ablative (CO2, Erbium-YAG) light-assisted methods