Impact of epidermal growth factor receptor sensitizing mutations on outcomes of patients with non-small cell lung cancer treated with definitive thoracic radiation therapy: a systematic review and meta-analysis.

摘要: // Yu Yang Soon 1, 2, 3 , Balamurugan Vellayappan Jeremy Chee Seong Tey Cheng Nang Leong Wee Yao Koh and Ivan Weng Keong Tham 1 Department of Radiation Oncology, National University Cancer Institute, Singapore 2 Hospital, Singapore, Correspondence to: Soon, email: yysoon01@gmail.com Keywords: non-small cell lung cancer, epidermal growth factor receptor, radiotherapy, chemo-radiotherapy, prognosis Received: July 04, 2017      Accepted: August 29, Published: September 18, 2017 ABSTRACT Background: To determine if the presence receptor (EGFR) sensitizing mutations improves tumor control survival outcomes in patients with non-metastatic cancer (NSCLC) who received definitive thoracic radiation therapy (TRT) or without chemotherapy. Materials Methods: We searched MEDLINE for eligible comparative studies which compared treated TRT according to EGFR mutation status. Meta-analysis was performed using random effects model. Outcomes interest were overall response rate (ORR), loco-regional (LRR), distant recurrence rates (DRR), relapse-free (RFS), (OS) adverse events (AE). Results: found seven including 537 stage III NSCLC. Up 45% had exon 19 21. Patients harbouring a trend towards improvement ORR (risk ratio 1.17, 95% confidence interval 0.99–1.37, P = 0.06) wild type There no significant differences LRR, DRR, RFS, OS AE between mutant groups. Conclusions: The may improve tumour but not localized NSCLC