Hemimegalencephaly: Adult Evolution (P3.234)

摘要: OBJECTIVE/ BACKGROUND: Provide improved characterization of the evolution Hemimegalencephaly (HME) in adult patients. HME is a rare neurological migration disorder resulting enlargement one hemisphere. Depending on severity enlargement, clinical manifestations may include macrocephaly, colpocephaly, epilepsy, and impaired psychomotor development. also be associated with various neurocutaneous syndromes. One syndrome Hypomelanosis Ito (HI). The main characteristics HI are hypopigmented skin areas along lines Blaschko, which appear as streaks patches. DESIGN/METHODS: We retrospectively examined patients hemimegalencephaly by evaluating their current cognitive development, seizure control, documentation therapies for management outcomes. RESULTS: Five were included, 3 males, mean age ±23.8. Four had syndromes, while patient isolated hemimegalencephaly. Patients onset past seven years old better control development adulthood, comparison to within first year life. CONCLUSIONS: In our small sample patients, onset, disability, associated. Additionally, outcome compared syndromic cases. Disclosure: Dr. Wu has nothing disclose. Borlot Ali Krings Lozano received personal compensation activities Medtronic Inc., Boston Scientific Corp., Johnson & Johnson, St Jude Medical. an editorial capacity Brain Stimulation. Andrade