Lack of Correlation between DNA-dependent Protein Kinase Activity and Tumor Cell Radiosensitivity
作者： S. P. Lees-Miller , R. S. Day , G. M. Barron , M. J. Allalunis-Turner , L. G. Lintott
DOI:
关键词:
摘要: Lack of DNA-dependent protein kinase (DNA-PK) activity confers radiosensitivity and defective DNA double-strand break repair. Nine human malignant glioma cell lines were studied to determine whether differences in DNA-PK reflect inherent or are predictive tumor treatment response. was present all extracts, as the proteins, catalytic subunit, Ku p70, p80. No correlation found between levels These preliminary results suggest that variation may not be a determinant clinical response glioma.
aacrjournals.org参考文章(15)
Carl W. Anderson, Margery A. Connelly, Susan P. Lees-Miller, Lauri G. Lintott, Hong Zhang, John D. Sipley, Kazuyasu Sakaguchi, E. Appella, The human DNA-activated protein kinase, DNA-PK: Substrate specificity Other Information: PBD: 5 Nov 1994. pp. 395- 406 ,(1995) , 10.1007/978-1-4899-1031-8_35
P.R. Blier, A.J. Griffith, J. Craft, J.A. Hardin, Binding of Ku protein to DNA. Measurement of affinity for ends and demonstration of binding to nicks. Journal of Biological Chemistry. ,vol. 268, pp. 7594- 7601 ,(1993) , 10.1016/S0021-9258(18)53216-6
Olive Pl, Banáth Jp, MacPhail Hs, Lack of a correlation between radiosensitivity and DNA double-strand break induction or rejoining in six human tumor cell lines Cancer Research. ,vol. 54, pp. 3939- 3946 ,(1994)
Katharine O Hartley, David Gell, Graeme C.M Smith, Hong Zhang, Nullin Divecha, Margery A Connelly, Arie Admon, Susan P Lees-Miller, Carl W Anderson, Stephen P Jackson, DNA-dependent protein kinase catalytic subunit: A relative of phosphatidylinositol 3-kinase and the ataxia telangiectasia gene product Cell. ,vol. 82, pp. 849- 856 ,(1995) , 10.1016/0092-8674(95)90482-4
Tanya M. Gottlieb, Stephen P. Jackson, The DNA-dependent protein kinase: Requirement for DNA ends and association with Ku antigen Cell. ,vol. 72, pp. 131- 142 ,(1993) , 10.1016/0092-8674(93)90057-W
J.F. Ward, The yield of DNA double-strand breaks produced intracellularly by ionizing radiation: a review. International Journal of Radiation Biology. ,vol. 57, pp. 1141- 1150 ,(1990) , 10.1080/09553009014551251
D.T. Goodhead, J. Thacker, R. Cox, Effects of Radiations of Different Qualities on Cells: Molecular Mechanisms of Damage and Repair International Journal of Radiation Biology. ,vol. 63, pp. 543- 556 ,(1993) , 10.1080/09553009314450721
A. Suwa, M. Hirakata, Y. Takeda, S. A. Jesch, T. Mimori, J. A. Hardin, DNA-dependent protein kinase (Ku protein-p350 complex) assembles on double-stranded DNA Proceedings of the National Academy of Sciences of the United States of America. ,vol. 91, pp. 6904- 6908 ,(1994) , 10.1073/PNAS.91.15.6904
Erik de Vries, Wim van Driel, Wilma G. Bergsma, Annika C. Arnberg, Peter C. van der Vliet, HeLa nuclear protein recognizing DNA termini and translocating on DNA forming a regular DNA-multimeric protein complex☆ Journal of Molecular Biology. ,vol. 208, pp. 65- 78 ,(1989) , 10.1016/0022-2836(89)90088-0
C. Kirchgessner, C. Patil, J. Evans, C. Cuomo, L. Fried, T. Carter, M. Oettinger, J. Brown, DNA-dependent kinase (p350) as a candidate gene for the murine SCID defect Science. ,vol. 267, pp. 1178- 1183 ,(1995) , 10.1126/SCIENCE.7855601