Carcinoembryonic Antigen as a Vaccine Target

摘要: The human carcinoembryonic antigen (CEA) as a target for vaccine-mediated therapy of range cancers will be reviewed. first section provide an overview the CEA gene family and levels expression in neoplastic preneoplastic lesions, some normal fetal tissues. pros cons using animal models then discussed (a) defming optimal strategies inducing immune response antitumor to “self”-antigen such CEA, (b) prelude clinical studies. numerous studies that have now been carried out define immunogenicity humans reviewed; this also include on definition enhancer T-cell agonist epitope has shown enhance responses CEA. Finally, multiple can used further self-antigen including use vectors containing transgenes costimulatory molecules. potential implementation these vaccine trials discussed.