Functional Metabolomics Reveals Novel Active Products in the DHA Metabolome

摘要: Endogenous mechanisms for successful resolution of an acute inflammatory response and the local return to homeostasis are interest because excessive inflammation underlies many human diseases. In this review, we provide update overview functional metabolomics that identified a new bioactive metabolome docosahexaenoic acid (DHA). Systematic studies revealed DHA was converted DHEA-derived novel products as well aspirin-triggered (AT) forms protectins. The oxygenated DHEA derived blocked PMN chemotaxis, reduced P-selectin expression platelet-leukocyte adhesion, showed organ protection in ischemia/reperfusion injury. These activated cannabinoid receptor (CB2 receptor) not CB1 receptors. AT-PD1 neutrophil (PMN) recruitment murine peritonitis. With cells, decreased transendothelial migration enhanced efferocytosis apoptotic by macrophages. recent findings reviewed here indicate oxidative metabolism conversion produce potent molecules with anti-inflammatory organ-protective properties, opening roles.