Evaluation of CNS activity of Bramhi Ghrita

摘要: OBJECTIVE: To eavaluate the CNS activity of Bramhi Ghrita, a polyherbal formulation containing Bacopa monneri, Evolvulus alsinoids, Acorus calamus, Saussurea lappa and cow's ghee. MATERIALS AND METHODS: The effect Ghrita on motor coordination, behavior, sleep, convulsions, locomotion analgesia was evaluated in mice using standard procedures. RESULTS: exhibited reduced alertness, spontaneous locomotor reactivity. It also antagonized behavioral effects d-amphetamine, potentiated pentobarbitone-induced sleep increased pain threshold. protected from maximum electroshock pentylene tetrazole-induced convulsions.