Combating multidrug-resistant Plasmodium falciparum malaria.

摘要: Over the past 50 years, Plasmodium falciparum has developed resistance against all antimalarial drugs used it: chloroquine, sulphadoxine-pyrimethamine, quinine, piperaquine and mefloquine. More recently, to artemisinin derivatives resulting failure of artemisinin-based combination therapy (ACT) are threatening major gains made in malaria control. Each time progressively, with delayed clearance parasites first emerging only a few regions, increasing prevalence geographic range, then ultimately complete that antimalarial. Drawing from this repeated historical chain events, article presents context-specific approaches for combating drug-resistant P. malaria. The begin context drug-sensitive focus on prevention emergence drug resistance. Next, address scenario which emerged is extent, interventions focused disrupting transmission through vector control, early diagnosis treatment, use new therapies. Elimination also presented as an approach addressing imminent available antimalarials. final one antimalarials have failed; leaving personal protection (or combinations antimalarials) viable strategy dealing All effective strategies contexts require multipronged, holistic approach.