Downregulation of ribophorin II suppresses tumor growth, migration, and invasion of nasopharyngeal carcinoma.
作者： Feilong Hong , Yong Li , Haifeng Ni , Jing Li
DOI: 10.2147/OTT.S158355
关键词:
摘要: Background It has been reported that ribophorin II (RPN2) expression is increased in many cancers, but the role of RPN2 nasopharyngeal carcinoma (NPC) remains unclear. Patients and methods This study found dramatically NPC tissues patients compared with adjacent normal tissues. attempted at understanding effect siRNA-RPN2 treatment on migration invasion cell lines CNE2 HNE1. Results RT-PCR Western blotting showed was highly expressed HNE1 cells. significantly inhibited viability 24 48 h control group. transwell assay that, to groups, cells treated decreased markedly. In addition, caspase-3, caspase-9, E-cadherin levels MMP 2 siRNA-RPN2-treated Phosphorylation AKT PI3K also after treatment. Conclusion can effectively inhibit human via AKT/PI3K signaling. serve as a novel strategy for
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