Th17 profile in COPD exacerbations

摘要: COPD is characterized by an ongoing inflammatory process of the airways that leads to obstruction or limitation airflow. It mainly associated with exposure cigarette smoke. In addition, it considered, at present, a serious public health problem, ranking fourth in mortality worldwide. Many cells participate pathophysiology COPD, most important are neutrophils, macrophages and CD4+ CD8+ T cells. Neutrophil migration inflammation area could be mediated largely cytokines related Th17 lymphocytes, because has been shown IL-17A, IL-17F IL-22 act as inducers for CXCL8, CXCL1, CXCL5, G-CSF, GM-CSF secretion epithelial airways. The aims these molecules differentiation, proliferation recruitment neutrophils. Furthermore, believed lymphocytes may involved protection against pathogens which Th1 Th2 not prepared fight. exacerbations, there increased cellularity lung region respiratory tract. Therefore, increase number neutrophils proinflammatory directly severity exacerbations importance functions profile this entity.