Cutting Edge : Lung Mucosal Th17-Mediated Responses Induce Polymeric Ig Receptor Expression by the Airway Epithelium and Elevate Secretory IgA Levels
作者： Zeina Jaffar , Maria E. Ferrini , Lou A. Herritt , Kevan Roberts
关键词:
摘要: Polymeric Ig receptor (pIgR) is a central player in mucosal immunity that mediates the delivery of polymeric IgA and IgM to apical surface epithelial cells via transcytosis. Emerging evidence suggests Th17 not only mediate autoimmunity but also play key roles host defense against pathogens. We demonstrate OVA-specific CD4 + cells, addition causing neutrophilic inflammation mice, mediated pronounced influx CD19 B into lungs following Ag inhalation. Coincident with this recruitment was striking induction pIgR expression by bronchial epithelium subsequent increase airway secretory levels. Intranasal administration IL-17 revealed crucial role for cytokine inducing epithelium. These findings support pulmonary immune respiratory pathogens promoting pIgR-mediated transport airway.
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