The different functions of Norrin.
作者： Barbara M. Braunger , Ernst R. Tamm
DOI: 10.1007/978-1-4614-0631-0_86
关键词:
摘要: Norrin is a secreted protein which encoded by the NDP gene mutated in Norrie disease. In eye, major site of expression Muller glia. activates canonical Wnt/β-catenin signaling pathway via specific binding to frizzled (Fzd)4/low-density lipoprotein receptor-related (Lrp)5/6 receptor complex, and part an essential system that controls formation retinal capillaries during development. Independent from its angiogenic function, has pronounced neuroprotective properties on ganglion cells activation Wnt/β-Catenin subsequent induction neurotrophic growth factors cells. addition, there evidence uterus placenta required for reproduction
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E Lütjen-Drecoll, U Welge-Lüssen, W Berger, J Gottanka, C A May, M Richter, Retinal Vasculature Changes in Norrie Disease Mice Investigative Ophthalmology & Visual Science. ,vol. 39, pp. 2450- 2457 ,(1998)
Mette Warburg, Norrie's disease. A congenital progressive oculo-acoustico-cerebral degeneration. Acta Ophthalmologica. ,(1966)
Heidi L. Rehm, Duan-Sun Zhang, M. Christian Brown, Barbara Burgess, Chris Halpin, Wolfgang Berger, Cynthia C. Morton, David P. Corey, Zheng-Yi Chen, Vascular Defects and Sensorineural Deafness in a Mouse Model of Norrie Disease The Journal of Neuroscience. ,vol. 22, pp. 4286- 4292 ,(2002) , 10.1523/JNEUROSCI.22-11-04286.2002
Xin Ye, Yanshu Wang, Hugh Cahill, Minzhong Yu, Tudor C. Badea, Philip M. Smallwood, Neal S. Peachey, Jeremy Nathans, Norrin, Frizzled-4, and Lrp5 Signaling in Endothelial Cells Controls a Genetic Program for Retinal Vascularization Cell. ,vol. 139, pp. 285- 298 ,(2009) , 10.1016/J.CELL.2009.07.047
Ulrich F. O. Luhmann, Jihong Lin, Niyazi Acar, Stefanie Lammel, Silke Feil, Christian Grimm, Mathias W. Seeliger, Hans-Peter Hammes, Wolfgang Berger, Role of the Norrie disease pseudoglioma gene in sprouting angiogenesis during development of the retinal vasculature. Investigative Ophthalmology & Visual Science. ,vol. 46, pp. 3372- 3382 ,(2005) , 10.1167/IOVS.05-0174
Johane Robitaille, Marcia L.E. MacDonald, Ajamete Kaykas, Laird C. Sheldahl, Jutta Zeisler, Marie-Pierre Dubé, Lin-Hua Zhang, Roshni R. Singaraja, Duane L. Guernsey, Binyou Zheng, Lee F. Siebert, Ann Hoskin-Mott, Michael T. Trese, Simon N. Pimstone, Barkur S. Shastry, Randall T. Moon, Michael R. Hayden, Y. Paul Goldberg, Mark E. Samuels, Mutant frizzled-4 disrupts retinal angiogenesis in familial exudative vitreoretinopathy. Nature Genetics. ,vol. 32, pp. 326- 330 ,(2002) , 10.1038/NG957
Andreas Ohlmann, Michael Scholz, Andreas Goldwich, Bharesh K Chauhan, Kristiane Hudl, Anne V Ohlmann, Eberhart Zrenner, Wolfgang Berger, Aleš Cvekl, Mathias W Seeliger, Ernst R Tamm, Ectopic norrin induces growth of ocular capillaries and restores normal retinal angiogenesis in Norrie disease mutant mice. The Journal of Neuroscience. ,vol. 25, pp. 1701- 1710 ,(2005) , 10.1523/JNEUROSCI.4756-04.2005
Alfons Meindl, Bright Lorenz, Helene Achatz, Heide Hellebrand, Peter Schmitz-Valckenberg, Thomas Meitinger, Missense mutations in the NDP gene in patients with a less severe course of Norrie disease. Human Molecular Genetics. ,vol. 4, pp. 489- 490 ,(1995) , 10.1093/HMG/4.3.489
A. Ohlmann, R. Seitz, B. Braunger, D. Seitz, M. R. Bosl, E. R. Tamm, Norrin Promotes Vascular Regrowth after Oxygen-Induced Retinal Vessel Loss and Suppresses Retinopathy in Mice The Journal of Neuroscience. ,vol. 30, pp. 183- 193 ,(2010) , 10.1523/JNEUROSCI.3210-09.2010
Isabella Torrente, Massimo Mangino, Massimo Gennarelli, Giuseppe Novelli, Aldo Giannotti, Pasquale Vadalà, Bruno Dallapiccola, Two new missense mutations (A105T and C110G) in the Norrin gene in two Italian families with Norrie disease and familial exudative vitreoretinopathy American Journal of Medical Genetics. ,vol. 72, pp. 242- 244 ,(1997) , 10.1002/(SICI)1096-8628(19971017)72:2<242::AID-AJMG23>3.0.CO;2-M