In vivo volumetric depth-resolved vasculature imaging of human limbus and sclera with 1 μm swept source phase-variance optical coherence angiography

作者: Raju Poddar , Robert J Zawadzki , Dennis E Cortés , Mark J Mannis , John S Werner

DOI: 10.1088/2040-8978/17/6/065301

关键词:

摘要: We present nnnnnin vivo volumetric depth-resolved vasculature images of the anterior segment human eye acquired with phase-variance based motion contrast using a high-speed (100 kHz, 105 A-scans/s) swept source optical coherence tomography system (SSOCT). High phase stability SSOCT imaging was achieved by computationally efficient stabilization approach. The corneo-scleral junction and sclera were imaged angiography compared slit lamp from same eyes normal subjects. Different features rich vascular in conjunctiva episclera visualized described. This can be used as potential tool for ophthalmological research to determine changes outflow system, which may helpful identification abnormalities that lead glaucoma.

参考文章(29)
Boy Braaf, Koenraad A. Vermeer, Victor Arni D.P. Sicam, Elsbeth van Zeeburg, Jan C. van Meurs, Johannes F. de Boer, Phase-stabilized optical frequency domain imaging at 1-µm for the measurement of blood flow in the human choroid Optics Express. ,vol. 19, pp. 20886- 20903 ,(2011) , 10.1364/OE.19.020886
Maciej Szkulmowski, Anna Szkulmowska, Tomasz Bajraszewski, Andrzej Kowalczyk, Maciej Wojtkowski, Flow velocity estimation using joint Spectral and Time domain Optical Coherence Tomography Optics Express. ,vol. 16, pp. 6008- 6025 ,(2008) , 10.1364/OE.16.006008
Sujiv Vurgese, Songhomitra Panda-Jonas, Jost B. Jonas, Scleral Thickness in Human Eyes PLoS ONE. ,vol. 7, pp. e29692- ,(2012) , 10.1371/JOURNAL.PONE.0029692
Hansford C. Hendargo, Ryan P. McNabb, Al-Hafeez Dhalla, Neal Shepherd, Joseph A. Izatt, Doppler velocity detection limitations in spectrometer-based versus swept-source optical coherence tomography Biomedical Optics Express. ,vol. 2, pp. 2175- 2188 ,(2011) , 10.1364/BOE.2.002175
Peng Li, Lin An, Roberto Reif, Tueng T. Shen, Murray Johnstone, Ruikang K Wang, In vivo microstructural and microvascular imaging of the human corneo-scleral limbus using optical coherence tomography Biomedical Optics Express. ,vol. 2, pp. 3109- 3118 ,(2011) , 10.1364/BOE.2.003109
Benjamin Potsaid, Bernhard Baumann, David Huang, Scott Barry, Alex E. Cable, Joel S. Schuman, Jay S. Duker, James G. Fujimoto, Ultrahigh speed 1050nm swept source/Fourier domain OCT retinal and anterior segment imaging at 100,000 to 400,000 axial scans per second. Optics Express. ,vol. 18, pp. 20029- 20048 ,(2010) , 10.1364/OE.18.020029
Shuichi Makita, Youngjoo Hong, Masahiro Yamanari, Toyohiko Yatagai, Yoshiaki Yasuno, Optical coherence angiography Optics Express. ,vol. 14, pp. 7821- 7840 ,(2006) , 10.1364/OE.14.007821
Jeff Fingler, Robert J. Zawadzki, John S. Werner, Dan Schwartz, Scott E. Fraser, Volumetric microvascular imaging of human retina using optical coherence tomography with a novel motion contrast technique Optics Express. ,vol. 17, pp. 22190- 22200 ,(2009) , 10.1364/OE.17.022190