Dnmt3L and the Establishment of Maternal Genomic Imprints
作者： Déborah Bourc'his , Guo-Liang Xu , Chyuan-Sheng Lin , Brooke Bollman , Timothy H Bestor
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摘要: Complementary sets of genes are epigenetically silenced in male and female gametes in a process termed genomic imprinting. The Dnmt3L gene is expressed during gametogenesis at stages where genomic imprints are established. Targeted disruption of Dnmt3L caused azoospermia in homozygous males, and heterozygous progeny of homozygous females died before midgestation. Bisulfite genomic sequencing of DNA from oocytes and embryos showed that removal of Dnmt3L prevented methylation of sequences that are normally …
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