Vascular Endothelial Growth Factor Upregulates the Expression of Matrix Metalloproteinases in Vascular Smooth Muscle Cells: Role of flt-1
作者： He Wang , Joan A. Keiser
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摘要: Abstract—Vascular endothelial growth factor (VEGF) is a critical regulator of angiogenesis that stimulates proliferation, migration, and proteolytic activity cells. Although the mitogenic VEGF cell specific, recent reports indicate able to stimulate chemotaxis tissue production in monocytes. VEGF-stimulated monocytes mediated by receptor flt-1. The purpose present study was investigate effects on another major type vascular wall, namely, smooth muscle (SMC). Using cultured cells, we showed has minimal effect SMCs, which accordance with published data. However, treatment significantly enhanced matrix metalloproteinase (MMP)-1, -3, -9 human SMCs. upregulation MMP-1 MMP-9 pronounced, stimulation for MMP-3 less prominent. Stimulation could be demonstrated at both protein mRNA levels, as r...
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