Resistance of Aryl-Substituted Phenylalanines to Decarboxylation in the Rat
作者： Brian L. Goodwin , Colin R.J. Ruthven , Merton Sandler
DOI: 10.1016/S0306-3623(98)00017-2
关键词:
摘要: Abstract 1. The in vivo decarboxylation of analogues DL -phenylalanine with methoxy, ethoxy or methylenedioxy substituents on the aromatic nucleus was assessed rat by measuring urinary excretion corresponding phenylacetic acids and β-phenylethylamines. Only trace amounts these amines were excreted. 2. ο -Tyrosine readily decarboxylated, a property that may be attributed to position nature substituent nucleus. 3. Some phenylpyruvic derived from amino exhibited certain degree reduction phenyllactic rat.
elsevier.com
sci-hub.se 参考文章(21)
Y. Gopalakrishna, T.K. Narayanan, G. Ramananda Rao, Biosynthesis of β-phenethyl alcohol in Candida guilliermondii Biochemical and Biophysical Research Communications. ,vol. 69, pp. 417- 422 ,(1976) , 10.1016/0006-291X(76)90538-6
Hazel R. Bloxam, M. G. Day, Nancy K. Gibbs, L. I. Woolf, An inborn defect in the metabolism of tyrosine in infants on a normal diet Biochemical Journal. ,vol. 77, pp. 320- 326 ,(1960) , 10.1042/BJ0770320
Ernest Frederick Gale, The production of amines by bacteria: The decarboxylation of amino-acids by strains of Bacterium coli. Biochemical Journal. ,vol. 34, pp. 392- 413 ,(1940) , 10.1042/BJ0340392
P.S. Cammarata, Philip P. Cohen, The scope of the transamination reaction in animal tissues. Journal of Biological Chemistry. ,vol. 187, pp. 439- 452 ,(1950) , 10.1016/S0021-9258(19)50969-3
Antony J. Hannaford, Peter W. G. Smith, Austin R. Tatchell, Brian S. Furniss, Vogel's Textbook of Practical Organic Chemistry ,(1996)
Erwin Schwenk, Edith Bloch, A New Modification of Willgerodt's Reaction Journal of the American Chemical Society. ,vol. 64, pp. 3051- 3052 ,(1942) , 10.1021/JA01264A515
A. Brossi, F. Schenker, R. Schmidt, R. Banziger, W. Leimgruber, Synthesen in der Isochinolinreihe Zur Darstellung 6,7,8-Hydroxy-dimethoxy-substituierter 1,2,3,4-Tetrahydro-isochinoline aus 3-Benzyloxy-4, 5-dimethoxy-phenathylamin und Bericht über die Resultate der pharmakologischen Prüfung von Anhalamin, Anhalidin,rac.Anhalonidin undrac.Pellotin Helvetica Chimica Acta. ,vol. 49, pp. 403- 411 ,(1966) , 10.1002/HLCA.660490145
B. L. Goodwin, C. R. J. Ruthven, G. S. King, M. Sandler, B. G. S. Leask, Metabolism of 3, 4-dihydroxyphenylalanine, its metabolites and analogues in vivo in the rat: urinary excretion pattern. Xenobiotica. ,vol. 8, pp. 629- 651 ,(1978) , 10.3109/00498257809069575
B.L. Goodwin, C.R.J. Ruthven, M. Sandler, Gas chromatographic estimation of urinary homovanillic and 4-hydroxy-3-methoxymandelic acids using capillary columns. Clinica Chimica Acta. ,vol. 55, pp. 111- 112 ,(1974) , 10.1016/0009-8981(74)90342-8
B.L. Goodwin, M. Sandler, Improved resolution using capillary columns Clinica Chimica Acta. ,vol. 59, pp. 253- 254 ,(1975) , 10.1016/0009-8981(75)90038-8