Postnatal changes in O2 and CO2 sensitivity in rodents.

摘要: Abstract In rodents, the ventilatory responses to hypoxia (low O2) and hypercarbia (high CO2) change significantly over postnatal development. hypoxia, most adult rodents increase ventilation decrease metabolism some degree. Hypercarbia, however, leads an in with little, no metabolism. Neonates, on other hand, respond a profound metabolic depression, severely attenuated response. hypercarbia, they exhibit strong response early development that blunts, reaches nadir, then rises back adult-like response, thus, stabilizing postnatally. this review we discuss how O2 CO2 develop possible mechanisms drive these changes, being raised burrow, environment putatively low high CO2, may affect of sensitivity rodents.