Chemical Classification and Structure— Odour Relationships

摘要: The physical and chemical properties required of a suitable sensory active molecule are determined by the location, molecular architecture physiological medium chemoreceptor. Clearly activity in human olfaction is exclusively associated with volatile molecules. higher limit weight found for odorants around 300 (for some examples, see Refs 1–3). Chemical reactivity ligand has little if any direct connection olfactory since odorant molecules uncharged hardly require metabolic activation. Nevertheless, several requirements must be met. Thus most odorous contain both strong hydrophobic relatively weak polar region. latter, usually termed ‘osmophore’,4 functional group such as carbonyl, hydroxyl, occasionally an ether or limited variety heteroatomic homologues. However, presence not conditio sine qua non receptor interaction. Even alkanes can have distinctive odours.