Impaired regulation of adipose tissue lipoprotein lipase in obesity.

摘要: Among the numerous alterations in adipose tissue metabolism obesity is an increased activity of lipoprotein lipase (LPL), rate-limiting enzyme triglyceride assimilation. The present paper summarizes a series experiments demonstrating that regulation LPL also impaired obesity. In normal subjects, glucose intake leads to increase activity; this phenomenon can be demonstrated by incubation insulin-containing buffer vitro. contrast, initially high from obese subjects non-responsive and insulin vivo However, absence led rapid decline elicited response subsequent exposure insulin. These data indicate hyperinsulinemia donor may importance for abnormalities activity. with VMH-lesioned rats levels activities could dissociated. normal-weight rats, standardized regard abolition endogenous production streptozotocin treatment substitution identical doses insulin, differed markedly, indicating factors other than are involved dysregulation