Exposure to colony stimulating factor 2 during preimplantation development increases postnatal growth in cattle

摘要: The microenvironment of a preimplantation embryo can influence changes in development that affect postnatal phenotypes. One the potential mediators this effect many species is colony-stimulating factor (CSF2), which increase an embryo's ability to establish pregnancy after its transfer into recipients. Exposure embryos CSF2 during early also pattern later sex-dependent manner. We therefore hypothesized treatment vitro-produced with culture would alter birth weight and growth resultant calf. Body withers height were measured for Holstein heifer calves produced vitro or without 10 ng/ml by artificial insemination. There no differences between groups; thereafter, however, from CSF2-treated group experienced greater increases body through 13 months age, only small height. These results support model characteristics be programmed period, one embryokines programming directed. Mol. Reprod. Dev. 82: 892-897, 2015. © 2015 Wiley Periodicals, Inc.