Facile preparation of hyaluronic acid-modified Fe3O4@Mn3O4 nanocomposites for targeted T1/T2 dual-mode MR imaging of cancer cells
作者： Jingchao Li , Yong Hu , Wenjie Sun , Yu Luo , Xiangyang Shi
DOI: 10.1039/C6RA05648B
关键词:
摘要: We report a facile approach to synthesizing hyaluronic acid (HA)-modified Fe3O4@Mn3O4 nanocomposites (NCs) for targeted T1/T2 dual-mode magnetic resonance (MR) imaging of cancer cells. In this work, branched polyethyleneimine (PEI)-coated NCs (Fe3O4@Mn3O4-PEI NCs) were first synthesized via one-pot hydrothermal route, followed by modification HA on the particle surface PEI amines. The formed Fe3O4@Mn3O4-PEI-HA well characterized different techniques. Our results manifest that possess good water dispersibility, colloidal stability, cytocompatibility in studied concentration range, and targeting specificity CD44 receptor-overexpressing Due coexistence Fe3O4 Mn3O4 particles, display relatively high r2 (143.26 mM−1 s−1) r1 (2.15 relaxivities, can be used as an efficient nanoprobe MR cells vitro. developed may hold great promise nanoplatform theranostics biological systems.
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