Biomarkers identification in fibromyalgia syndrome

摘要: Fibromyalgia Syndrome (FMS) is a chronic syndrome characterized by widespread pain. FMS collection of other symptoms and overlapping conditions contribute to complicate the diagnosis, assessment treatment. Unknown etiology none laboratory tests have been appropriately validated for diagnosis disease. The comparison protein patterns in body fluids diseased healthy subjects has potential identify new disease-specific biomarkers. Some purine nucleotide metabolism disorders such as myoadenylate deaminase (MAD) deficiency report similar those seen FMS. In consideration what described above, we carried out serum proteomic analysis patients with respect control searching potentially useful biomarkers In addition, evaluated metabolite concentrations affected relationships between their levels clinical parameters. Twenty-two females (according American College Rheumatology, 1990) twenty-two women were recruited controls metabolite. Sixteen twelve enrolled study analyses proteome. Proteomic was performed combining two-dimensional gel electrophoresis (2-DE) mass spectrometry (MS) quantified using reverse phase high performance liquid chromatographic (RP-HPLC). In our study, approach, identified differentially expressed proteins, Transthyretin (TTR), Alpha-1 Antitrypsin (A1AT) Retinol Binding Protein 4 (RBP4). these proteins significantly higher compared controls. TTR RBP4 are retinoid transporters, moreover dysfunction related oxidative stress well A1AT. These results support hypothesis that could be implicated pathophysiology FMS. Moreover, considerably concentration inosine, hypoxanthine xanthine (p<0.001) lower adenosine (p<0.05) detected when Our data show negative correlation Impact Questionnaire (FIQ). Our suggest purines, particular may involved pain transmission fibromyalgia.