Nitric oxide produced by iNOS is associated with collagen synthesis in keloid scar formation.
作者： Yi-Chiang Hsu , Michael Hsiao , Leng-Fang Wang , Yie W. Chien , Woan-Ruoh Lee
DOI: 10.1016/J.NIOX.2006.01.006
关键词:
摘要: Nitric oxide (NO) has emerged as an important mediator of many physiological functions. Recent reports have shown that NO participates in the wound healing process, however, its role in keloid formation remains unclear. This study aimed to investigate the effect of NO on keloid fibroblasts (KF) and to determine the levels of inducible nitric oxide synthase (iNOS) expression in clinical specimens of keloid. Scar tissue from seven keloid patients with matched perilesion skin tissue controls was studied for inducible nitric oxide synthase …
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