Impact of Heterogeneity of Human Peripheral Blood Monocyte Subsets on Myocardial Salvage in Patients With Primary Acute Myocardial Infarction

作者: Hiroto Tsujioka , Toshio Imanishi , Hideyuki Ikejima , Akio Kuroi , Shigeho Takarada

DOI: 10.1016/J.JACC.2009.04.021

关键词:

摘要: Objectives We examined whether distinct monocyte subsets contribute in specific ways to myocardial salvage patients with acute infarction (AMI). Background Recent studies have shown that monocytes human peripheral blood are heterogeneous. Methods studied 36 primary AMI. Peripheral sampling was performed 1, 2, 3, 4, 5, 8, and 12 days after AMI onset. Two (CD14+CD16−and CD14+CD16+) were measured by flow cytometry. The extent of 7 evaluated cardiovascular magnetic resonance imaging as the difference between myocardium at risk (T2-weighted hyperintense lesion) necrosis (delayed gadolinium enhancement). Cardiovascular also 6 months Results Circulating CD14+CD16−and CD14+CD16+monocytes increased patients, peaking on 3 5 onset, respectively. Importantly, peak levels CD14+CD16−monocytes, but not those CD14+CD16+monocytes, significantly negatively associated salvage. found correlated recovery left ventricular ejection fraction infarction. Conclusions CD14+CD16−monocytes affect both function AMI, indicating manipulation heterogeneity could be a novel therapeutic target for salvaging ischemic damage.

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