Multi-arm polymeric conjugates of 7-ethyl-10-hydroxycamptothecin for treatment of breast, colorectal, pancreatic, ovarian and lung cancers

作者: Dechun Wu , Hong Zhao , Puja Sapra , Maria Belen Rubio

DOI:

关键词:

摘要: A four arm-polyethylene glycol-7-ethyl-l0-hydroxycamptothecin conjugate, such as Formula (I), is disclosed. Methods of making the conjugates and methods treating mammals using same are also

参考文章(94)
Pendri A, Conover Cd, Greenwald Rb, Shum Kl, Camptothecin delivery systems: the utility of amino acid spacers for the conjugation of camptothecin with polyethylene glycol to create prodrugs. Anti-cancer Drug Design. ,vol. 14, pp. 499- 506 ,(1999)
Michael D. Bentley, Xuan N Building Xiao Huang Zhao, Harold Zappe, Polymer-based compositions and conjugates of hiv entry inhibitors ,(2005)
B. Rao Vishnuvajjala, Aaron Garzon-Aburbeh, Water soluble prodrugs of camptothecin ,(1987)
Antoni Kozlowski, Lihong Guo, J. Milton Harris, Method of preparing carboxylic acid functionalized polymers ,(2004)
Hiroshi Kuga, Yasuhide Hirota, Yasuyoshi Kawato, Keiki Sato, Masashi Aonuma, Intracellular Roles of SN-38, a Metabolite of the Camptothecin Derivative CPT-11, in the Antitumor Effect of CPT-11 Cancer Research. ,vol. 51, pp. 4187- 4191 ,(1991)
Katsuki Sugiyama, Ken Omachi, Keiichi Fujiwara, Takashi Saotome, Nobuyuki Mizunuma, Shunji Takahashi, Yoshinori Ito, Keisuke Aiba, Noboru Horikoshi, Irinotecan hydrochloride for the treatment of recurrent and refractory non-Hodgkin lymphoma: a single institution experience. Cancer. ,vol. 94, pp. 594- 600 ,(2002) , 10.1002/CNCR.10266
Xuan Zhao, Michael David Bentley, Polymer conjugates of protein kinase c inhibitors ,(2002)
Kees Fluiter, Frank Baas, Bo Hansen, Majken Westergaard, Rna antagonist compounds for the modulation of p21 ras expression ,(2006)