Antacid versus Cimetidine in Preventing Acute Gastrointestinal Bleeding

摘要: Over a 15-month period, 75 critically ill patients at risk of acute gastrointestinal bleeding were randomized into two groups: one group (38 patients) received the H2-blocker cimetidine intravenously an initial dosage 300 mg every six hours, and other (37 antacid (Mylanta II) through nasogastric tube intial 30 ml hour. Gastric pH was measured hourly titrated above 3.5. Upper-gastrointestinal-tract occurred in seven 38 cimetidine-treated but none 37 antacid-treated (P less than 0.01). When titration added to regimen four with bleeding, all stopped bleeding. Renal failure, sepsis, peritonitis, hypotension, respiratory jaundice, multiple trauma, major operative procedures associated increased incidence Cimetidine does not adequately protect seriously from upper-gastrointestinal-tract Antacid is better for this purpose.