Development and characterization of new flavivirus-resistant mouse strains bearing Flv(r)-like and Flv(mr) alleles from wild or wild-derived mice.
作者： N Urosevic , O J Silvia , M Y Sangster , J P Mansfield , S I Hodgetts
DOI: 10.1099/0022-1317-80-4-897
关键词:
摘要: A single genetic locus, flavivirus resistance (Flv), controls virus titres and severity of infection in mouse brain. It has been mapped to chromosome 5 shown include different allelic forms. While the majority laboratory strains are susceptible flaviviruses carry Flv(s) allele, wild mice recently derived from them resistant flavivirus-resistance alleles including Flv(r)-like Flv(mr) alleles. Although there is a model conferred by Flv(r) other have not adequately studied due lack appropriate animal models. In this paper we describe development new flavivirus-resistant strains, C3H.M.domesticus-Flv(r) C3H.MOLD-Flv(mr), which novel on background C3H/HeJ mice. The were created 10 11 generations backcrossing followed brother-sister matings resulting generation homozygous founder stocks. Genome analysis newly developed revealed chromosomal regions approximately 9 cM, respectively, encompassing Flv 5, donor These segments much smaller than segment 31 cM described congenic strain C3H.PRI-Flv(r) (also known as C3H/RV). standardized mice, represent models these
eurekamag.com参考文章(23)
M. Y. Sangster, G. R. Shellam, Genetically controlled resistance to flaviviruses within the house mouse complex of species. Current Topics in Microbiology and Immunology. ,vol. 127, pp. 313- 318 ,(1986) , 10.1007/978-3-642-71304-0_37
N Urosevic, J P Mansfield, G R Shellam, J S Mackenzie, M van Maanen, Molecular characterization of virus-specific RNA produced in the brains of flavivirus-susceptible and -resistant mice after challenge with Murray Valley encephalitis virus. Journal of General Virology. ,vol. 78, pp. 23- 29 ,(1997) , 10.1099/0022-1317-78-1-23
M C Green, Catalog of mutant genes and polymorphic loci. pp. 8- ,(1981)
M A Brinton, Analysis of extracellular West Nile virus particles produced by cell cultures from genetically resistant and susceptible mice indicates enhanced amplification of defective interfering particles by resistant cultures. Journal of Virology. ,vol. 46, pp. 860- 870 ,(1983) , 10.1128/JVI.46.3.860-870.1983
M Y Sangster, D B Heliams, J S MacKenzie, G R Shellam, Genetic studies of flavivirus resistance in inbred strains derived from wild mice: evidence for a new resistance allele at the flavivirus resistance locus (Flv). Journal of Virology. ,vol. 67, pp. 340- 347 ,(1993) , 10.1128/JVI.67.1.340-347.1993
Christian W. Mandl, Heidemarie Holzmann, Tamara Meixner, Susanne Rauscher, Peter F. Stadler, Steven L. Allison, Franz X. Heinz, Spontaneous and Engineered Deletions in the 3′ Noncoding Region of Tick-Borne Encephalitis Virus: Construction of Highly Attenuated Mutants of a Flavivirus Journal of Virology. ,vol. 72, pp. 2132- 2140 ,(1998) , 10.1128/JVI.72.3.2132-2140.1998
Clara J. Lynch, Thomas P. Hughes, The Inheritance of Susceptibility to Yellow Fever Encephalitis in Mice. Genetics. ,vol. 21, pp. 104- 112 ,(1936) , 10.1093/GENETICS/21.2.104
CG Liehne, S Leivers, NF Stanley, MP Alpers, S Paul, PFS Liehne, KH Chan, Ord River arboviruses--isolations from mosquitoes. Immunology and Cell Biology. ,vol. 54, pp. 499- 504 ,(1976) , 10.1038/ICB.1976.50
William F. Dietrich, Joyce C. Miller, Robert G. Steen, Mark Merchant, Deborah Damron, Robert Nahf, Alec Gross, Diane C. Joyce, Michael Wessel, Robert D. Dredge, Andre Marquis, Lincoln D. Stein, Nathan Goodman, David C. Page, Eric S. Lander, A genetic map of the mouse with 4,006 simple sequence length polymorphisms. Nature Genetics. ,vol. 7, pp. 220- 245 ,(1994) , 10.1038/NG0694SUPP-220
M. Y. Sangster, J. S. Mackenzie, G. R. Shellam, Genetically determined resistance to flavivirus infection in wild Mus musculus domesticus and other taxonomic groups in the genus Mus Archives of Virology. ,vol. 143, pp. 697- 715 ,(1998) , 10.1007/S007050050324