Methods of treating cerebral edema and spinal cord edema

摘要: The present invention relates to the use of selective aquaporin inhibitors, e.g., aquaporin-4 or aquaporin-2, certain phenylbenzamide compounds, for prophylaxis, treatment and control aquaporin-mediated conditions, diseases water imbalance, example edema (particularly brain spinal cord, following trauma ischemic stroke, as well associated with glioma, meningitis, acute mountain sickness, epileptic seizures, infections, metabolic disorders, hypoxia, intoxication, hepatic failure, encephalopathy, diabetic ketoacidosis, abscess, eclampsia, Creutzfeldt-Jakob disease, lupus cerebritis, consequent microgravity and/or radiation exposure, invasive central nervous system procedures, neurosurgery, endovascular clot removal, tap, aneurysm repair, deep stimulation, retinal edema), hyponatremia excess fluid retention, such epilepsy, ischemia other eye abnormalities in intraocular pressure tissue hydration, myocardial ischemia, ischemia/reperfusion injury, infarction, congestive heart sepsis, neuromyelitis optica, migraines, novel assays identifying inhibitors.