Deletion of Peg10, an imprinted gene acquired from a retrotransposon, causes early embryonic lethality

摘要: By comparing mammalian genomes, we and others have identified actively transcribed Ty3/gypsy retrotransposon-derived genes with highly conserved DNA sequences insertion sites1,2,3,4,5,6. To elucidate the functions of evolutionarily in development, produced mice that lack one these genes, Peg10 (paternally expressed 10)1,2,3,7, which is a paternally imprinted gene on mouse proximal chromosome 6. The knockout showed early embryonic lethality owing to defects placenta. This indicates critical for parthenogenetic development provides first direct evidence an essential role development.