Consortia of living bacteria useful for treatment of microbiome dysbiosis

作者: Christophe Chassard , Gerhard Rogler , Tomas de Wouters , Christophe Lacroix

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摘要: The present invention relates to novel compositions comprising specific consortia of living bacteria strains; the manufacturing such compositions, particularly by co-cultivation; and use in pharmaceutical applications, as treatment diseases associated with intestinal microbiota dysbiosis, infections CDI (Clostridium difficile infection) IBD (Inflammatory bowel diseases)

参考文章(22)
M. Goodfellow, Erko. Stackebrandt, Nucleic acid techniques in bacterial systematics Wiley. ,(1991)
Muhammad Tanweer Khan, Oriana Rossi, Harry James Flint, Sylvia Helen Duncan, Jeremy Wells, Hermanus Josef Martinus Harmsen, Use of faecali bacterium prausnitzii htf-f (dsm 26943) to suppress inflammation. ,(2014)
M. P. Bryant, Commentary on the Hungate technique for culture of anaerobic bacteria The American Journal of Clinical Nutrition. ,vol. 25, pp. 1324- 1328 ,(1972) , 10.1093/AJCN/25.12.1324
Tore Midtvedt, Arnold Berstad, Peter Benno, Atti-La Dahlgren, Elisabeth Norin, Composition comprising anaerobically cultivated human intestinal microbiota ,(2012)
Mireia Lopez-Siles, Tanweer M. Khan, Sylvia H. Duncan, Hermie J. M. Harmsen, L. Jesús Garcia-Gil, Harry J. Flint, Cultured Representatives of Two Major Phylogroups of Human Colonic Faecalibacterium prausnitzii Can Utilize Pectin, Uronic Acids, and Host-Derived Substrates for Growth Applied and Environmental Microbiology. ,vol. 78, pp. 420- 428 ,(2012) , 10.1128/AEM.06858-11
Christophe Chassard, Christophe Lacroix, Carbohydrates and the human gut microbiota. Current Opinion in Clinical Nutrition and Metabolic Care. ,vol. 16, pp. 453- 460 ,(2013) , 10.1097/MCO.0B013E3283619E63
R F Wang, W W Cao, C E Cerniglia, PCR detection and quantitation of predominant anaerobic bacteria in human and animal fecal samples. Applied and Environmental Microbiology. ,vol. 62, pp. 1242- 1247 ,(1996) , 10.1128/AEM.62.4.1242-1247.1996
Hiroshi Maeda, Chiyo Fujimoto, Yasuhiro Haruki, Takemasa Maeda, Susumu Kokeguchi, Millan Petelin, Hideo Arai, Ichiro Tanimoto, Fusanori Nishimura, Shogo Takashiba, Quantitative real-time PCR using TaqMan and SYBR Green for Actinobacillus actinomycetemcomitans, Porphyromonas gingivalis, Prevotella intermedia, tetQ gene and total bacteria Fems Immunology and Medical Microbiology. ,vol. 39, pp. 81- 86 ,(2003) , 10.1016/S0928-8244(03)00224-4